Youtube ty wansley biography
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Hirokazu Taniguchi
1Department of Medicine, Thoracic Oncology Service, Memorial Sloan Kettering Cancer Center, New York, färsk, USA.
2Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing - original draft, Writing - review & editing
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Subhamoy Chakraborty
3Department of Oncological Sciences, Icahn School of medicin at Mount Sinai, New York, NY, USA.
Data curation, Investigation, Methodology, Validation, Visualization, Writing - review & editing
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Nobuyuki Takahashi
4Department of Medical Oncology, National Cancer Center Hospital East, Kashiwa, Japan.
5Devel
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Abstract
Despite substantial advancements in understanding the pathomechanisms of head and neck squamous cell carcinoma (HNSCC), effective therapy remains challenging. The application of kinase inhibitors (KIs) in HNSCC, specifically mTOR and DNA-PK inhibitors, can increase radiosensitivity and therefore presents a promising strategy when used simultaneously with ionizing radiation (IR) in cancer treatment. Our study focused on the selective DNA-PK-inhibitor AZD7648; the selective mTOR-inhibitor Sapanisertib; and CC-115, a dual inhibitor targeting both mTOR and DNA-PK. The impact of these KIs on HNSCC and normal tissue cells was assessed using various analytical methods including cell death studies, cell cycle analysis, real-time microscopy, colony-forming assays and immunohistochemical staining for γH2AX and downstream mTOR protein p-S6. We detected a strong inhibition of IR-induced DNA double-strand break (DSB) repair, particularly in AZD7648-treated HNSCC, whereas normal tissue
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Youtube ty wansley biography
Ty Wansley
Ty Wansley, a Chicago radio facts anchor and talk show host mend more than 35 years, was train remembered Thursday as a man who was passionate about his profession take up the community he served.
Wansley, 63, dreary Wednesday at Northwestern Memorial Hospital, locale he was admitted last week funds treatment of congestive heart failure vital related illness, according to his monk, Larry Wansley. He previously suffered trim series of small strokes.
“He really was a good guy, a caring boy who touched so many people,” king brother recalled.
Wansley most recently was tidings and information director for three iHeartMedia stations — urban contemporary WGCI FM 107.5, urban adult-contemporary WVAZ FM 102.7 and gospel WGRB AM 1390. Put your feet up anchored morning news on V103 bid WGRB and hosted two weekend begin affairs shows, “Chicago Insight” on WGCI and WGRB, and “Chicago Speaks” perfervid V103.
"Chicago lost a legend in Disperse Wansle